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The Gut-Brain Axis and Serotonin Signalling in Irritable Bowel Syndrome: A Meta-Analysis of Gut Microbiota and Metabolite Interactions

Introduction
Irritable bowel syndrome (IBS) is a complex and multifaceted disorder characterized by recurrent abdominal pain, discomfort, and altered bowel habits, in
the absence of any identifiable organic cause. (Alsolami2023)Despite its high prevalence and significant impact on quality of life, the precise etiology of IBS
remains elusive. However, emerging research points to a crucial role of the gutbrain axis (GBA) in the pathophysiology of IBS, with serotonin (5-
hydroxytryptamine or 5-HT) signaling playing a key part in this bidirectional communication network. This meta-analysis aims to delve into the intricacies of the
GBA and serotonin signaling in IBS, focusing specifically on the interactions between gut microbiota and metabolites. (Mishima & Ishihara, 2021)(Vahora et al.,
2020)(Bruta et al.2021)(Guzel & Mirowska-Guzel, 2022)(Kanova & Kohout, 2021)(Chen et al.2022)(Koopman et al.2021)(Tao et al.2022)(Bi et al.2021)(Bellini
et al.2021)

Submitted by:
Lana Zaylah
Supervisor:
Dr.Raheel Asghar
Date:September,2024
Department of Medicine – European International University – Paris
May 2024