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Translational Application of Exosome-Based Therapies in Regenerative Medicine by Optimising Clinical Protocols for Anti-Aging and Wound Repair in Diverse Populations

The emergence of exosome-based therapeutics represents a transformative advancement in the field of regenerative medicine, offering novel mechanisms for cellular communication, tissue repair, and anti-aging intervention. This doctoral study explores the translational application of NAD⁺-enhanced exosomes derived from mesenchymal stem cells (MSCs) from human umbilical cord sources, focusing on the optimization of clinical protocols for ocular surface regeneration, skin rejuvenation, and systemic repair across diverse populations.
The study adopts a translational research approach, integrating preclinical laboratory data, pilot clinical trials, and regulatory analysis within Malaysia’s CGTP and NPRA frameworks. Central to this investigation is Oculogics™, an MSC-derived eye exosome formulation evaluated for dry eye disease and ocular surface damage. Clinical outcomes demonstrated significant improvements in tear stability, epithelial regeneration, and patient comfort, establishing Malaysia as one of the pioneering nations in exosome-based ocular therapeutics.
Parallel studies on Exologics™, a dermal exosome formulation enriched with NAD⁺, exhibited enhanced skin elasticity, hydration, and cellular repair, confirming the potential of exosomes as next-generation biologics for anti-aging and wound healing. Comparative data across age and ethnicity further emphasized the necessity of population-specific optimization in regenerative protocols.

Submitted by: Phoebe Ong Peow Cheng
[EIU202524319666]
In Partial Fulfillment of the Requirements for the Degree of
Doctor of Health Sciences in Aesthetics and Regenerative Medicine
Supervisor: Dr. V.B.Kumaresan